The body tries to compensate for this by ordering the heart to pump harder to maintain normal flow by raising the blood pressure. The endothelial cells ultimately determine the health of your blood vessels and play a … The endothelium is vital to the proper functioning in the heart, in particular due to its production of nitric oxide (NO) which regulates vascular tone. Damaged endothelium therefore contributes to hypertension. Endothelium cells help to control toxic substances in the blood. Furthermore, this tissue has an embryonic mesodermal origin. The heart wall is divided into three layers: epicardium, myocardium, and endocardium. The endothelial layer has a tone that contributes to the control of blood pressure. It plays a number of roles that are important for the functioning of the cardiovascular system. Endothelium is a specialized type of epithelium found in the lining of blood and lymphatic vessels. Because it is adjacent to the bloodstream, the endothelium can signal a blood vessel’s muscle to respond to changes in pressure and inflammation. Far from being inert, it is metabolically active and produces a variety of vasoactive mediators. As mentioned earlier the endothelial cells do a lot more than just regulate blood flow with nitric oxide, so damaging them has many other consequences. However, research over the last 25 years has shown that the endothelium is an active, multi-functional organ that plays a vital role in metabolic, immunologic, and cardiovascular health. The endothelium is a thin membrane that coats the inside of blood vessels and the heart. The vascular endothelium is a monolayer of cells between the vessel lumen and the vascular smooth muscle cells. The endothelium weighs approximately 1 kg in the average patient and covers a total surface area of 4000 to 7000 square meters. Damage to the cardiovascular endothelium not only develops with heart disease, but is one of the first steps on the path to heart disease, detectable even before structural changes to the vessel wall are apparent. Endothelia are considered the “brains” of blood vessels. Also, it lines the heart cavities. The layer assists in the regulation of mechanisms involved in blood clotting. Superiorly, is the second layer: a subendocardial connective tissue which is continuous with the connective tissue of the myocardium. Damage to the endothelium contributes to the development of atherosclerosis, and hence to possible myocardial infarction and subsequent heart failu … Branches of the heart’s conduction system are immersed into the subendocardial layer. The endothelium is … The endothelium, which forms the inner cell lining of all blood vessels and lymphatics in the body, is a spatially distributed organ. The heart wall is composed of connective tissue, endothelium, and cardiac muscle. 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